![]() Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth.Vidaurre O-G#, Gascón S#, Deogracias R, Sobrado M, Cuadrado E, Montaner J, Rodríguez-Peña A, and M. Imbalance of neurotrophin receptor isoforms TrkB-FL/TrkB-T1 induces neuronal death in excitotoxicity.Dieni S, Matsumoto T, Dekkers M, Rauskolb S, Ionescu M, Deogracias R, Gundelfinger E-D, Kojima M, Nestel S, Frotscher M, Barde Y-A. BDNF and its pro-peptide are stored in presynaptic large dense core vesicles in brain neurons.C, Boege F, Lyu Y-L, Peters A, Barde Y-A, Schübeler D. Tiwari W, Burger L#, Nikoletopoulou V#, Deogracias R, Wirbelauer C, Murr R, Terranova R, Mielke. Topoisomerase IIβ binding to promoters in postmitotic cells modulates gene activity and regulates neuronal survival.Deogracias R*, Yazdani M*, Guy J, Poot RA, Bird A, Barde Y-A. Disease modeling using embryonic stem cells: MeCP2 regulates nuclear size and RNA synthesis in neurons.Deogracias R*, Bischoff V, Poirier F, Barde Y-A. Seizure-induced neuronal death is suppressed in the absence of the endogenous lectin Galectin1. ![]() Deogracias R*, Yazdani M*, Dekkers MP, Guy J, Ionescu MC, Vogt KE, Barde YA. Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome.Favuzzi E, Deogracias R*, Marques-Smith A*, Winterflood CM, Sánchez-Aguilera A, Mantoan L, Maeso P, Fernandes C, Ewers H, Rico B. Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican.The Microtubule Regulator NEK7 Coordinates the Wiring of Cortical Parvalbumin Interneurons.Deogracias R*, Favuzzi E*, Marques-Smith A, Maeso P, Jezequel J, Exposito-Alonso D, Balia M, Kroon T, Hinojosa AJ, Maraver EF, Rico B. Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits.Users should refer to the original published version of the material for the full abstract. No warranty is given about the accuracy of the copy. However, users may print, download, or email articles for individual use. Copyright of El Farmacéutico Hospitales is the property of Ediciones Mayo and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. Dysbiosis or imbalance of the normal microbiota in the intestinal tract can lead to certain mental disorders, such as depression and anxiety. Our microbiota influences our brain and intestine through the secretion of neuroactive substances, such as serotonin, norepinephrine, dopamine, glutamate, and gammaaminobutyric acid, and can also alter brain function indirectly through changes in the inflammatory state and immune, producing proinflammatory cytokines. Known as the microbiota-gut-brain axis, this relationship involves various afferent and efferent pathways, as well as the vagus nerve and the hypothalamic-pituitary-adrenal axis, and interacts through the immune, neuroendocrine, and neuronal systems. Every time more papers are published on the participation of the microbiota and its metabolites in the etiopathogenesis of neurodegenerative diseases, irritable bowel syndrome, autism, schizophrenia and depression. Abstract: The relationship between the gut microbiota and the central nervous system has been known for a long time.
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